Ontology highlight
ABSTRACT:
SUBMITTER: Zhang RW
PROVIDER: S-EPMC5025778 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nature communications 20160902
Glutamatergic retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. However, its initiation and underlying mechanism remain largely elusive. Here using larval zebrafish and multiple in vivo approaches, we discover that bipolar cells (BCs) are responsible for the generation of glutamatergic retinal waves. The wave originates from BC axon terminals (ATs) and propagates la ...[more]