Ontology highlight
ABSTRACT:
SUBMITTER: Qi X
PROVIDER: S-EPMC5030800 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20160822 10
Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans. In this study, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and autophagy. Mice and macrophages lacking cathepsin B activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida Genetic deletion or pharmacological inhibition ...[more]