Ontology highlight
ABSTRACT:
SUBMITTER: Duan L
PROVIDER: S-EPMC5042876 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160916 38
The final step in the biosynthesis of the sesquiterpenoid antibiotic pentalenolactone (1) is the highly unusual cytochrome P450-catalyzed, oxidative rearrangement of pentalenolactone F (2), involving the transient generation and rearrangement of a neopentyl cation. In Streptomyces arenae this reaction is catalyzed by CYP161C2 (PntM), with highly conserved orthologs being present in at least 10 other Actinomycetes. Crystal structures of substrate-free PntM, as well as PntM with bound substrate 2, ...[more]