Ontology highlight
ABSTRACT:
SUBMITTER: Boyle KM
PROVIDER: S-EPMC5061454 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Boyle Kelsey M KM Barton Jacqueline K JK
Inorganica chimica acta 20160116
DNA has been exploited as a biological target of chemotherapeutics since the 1940s. Traditional chemotherapeutics, such as cisplatin and DNA-alkylating agents, rely primarily on increased uptake by rapidly proliferating cancer cells for therapeutic effects, but this strategy can result in off-target toxicity in healthy tissue. Recently, research interests have shifted towards targeted chemotherapeutics, in which a drug targets a specific biological signature of cancer, resulting in selective tox ...[more]