Ontology highlight
ABSTRACT:
SUBMITTER: Gaudin A
PROVIDER: S-EPMC5072177 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Gaudin Alice A Song Eric E King Amanda R AR Saucier-Sawyer Jennifer K JK Bindra Ranjit R Desmaële Didier D Couvreur Patrick P Saltzman W Mark WM
Biomaterials 20160804
New treatments for glioblastoma multiforme (GBM) are desperately needed, as GBM prognosis remains poor, mainly due to treatment resistance, poor distribution of therapeutics in the tumor tissue, and fast metabolism of chemotherapeutic drugs in the brain extracellular space. Convection-enhanced delivery (CED) of nanoparticles (NPs) has been shown to improve the delivery of chemotherapeutic drugs to the tumor bed, providing sustained release, and enhancing survival of animals with intracranial tum ...[more]