Ontology highlight
ABSTRACT:
SUBMITTER: Carmi Y
PROVIDER: S-EPMC5085602 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Carmi Yaron Y Prestwood Tyler R TR Spitzer Matthew H MH Linde Ian L IL Chabon Jonathan J Reticker-Flynn Nathan E NE Bhattacharya Nupur N Zhang Hong H Zhang Xiangyue X Basto Pamela A PA Burt Bryan M BM Alonso Michael N MN Engleman Edgar G EG
JCI insight 20161103 18
BM-derived DC (BMDC) are powerful antigen-presenting cells. When loaded with immune complexes (IC), consisting of tumor antigens bound to antitumor antibody, BMDC induce powerful antitumor immunity in mice. However, attempts to employ this strategy clinically with either tumor-associated DC (TADC) or monocyte-derived DC (MoDC) have been disappointing. To investigate the basis for this phenomenon, we compared the response of BMDC, TADC, and MoDC to tumor IgG-IC. Our findings revealed, in both mic ...[more]