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Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L.

ABSTRACT: Three novel 2,3-diaryl indone derivatives, ascomindones A-C (1-3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6-9) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the interpretation of spectroscopic data. 1 and 4 were further constructed by analysis of X-ray diffraction. Antioxidant properties based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavenging activities and the ferric reducing ability power (FRAP) of the new compounds were assayed. All of them exhibited significant effects, of which 1 showed more potent activity than ascorbic acid in scavenging DPPH radical with IC50 value of 18.1??M.

SUBMITTER: Tan C

PROVIDER: S-EPMC5095669 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L.

Tan Chunbin C Liu Zhaoming Z Chen Senhua S Huang Xishan X Cui Hui H Long Yuhua Y Lu Yongjun Y She Zhigang Z

Scientific reports 20161104

Three novel 2,3-diaryl indone derivatives, ascomindones A-C (1-3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6-9) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the interpretation of spectroscopic data. 1 and 4 were further constructed by analysis of X-ray diffraction. Antioxidant properties based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavengi ...[more]

PMID: 27811993

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