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Spirobisnaphthalenes from the mangrove-derived fungus Rhytidhysteron sp. AS21B.

ABSTRACT: Three new spirobisnaphthalenes (1-3) were isolated from the mangrove-derived fungus Rhytidhysteron sp., together with five known derivatives (4-8). The structures of the compounds were established on the basis of extensive spectroscopic data, and the relative configurations of their stereogenic carbons were determined by a single-crystal X-ray crystallographic analysis. Compounds 3-5 displayed cytotoxicity against both cancer cell lines, MCF-7 and CaSki, while 2 was active only on CaSKi cells.

SUBMITTER: Pudhom K

PROVIDER: S-EPMC3967209 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Spirobisnaphthalenes from the mangrove-derived fungus Rhytidhysteron sp. AS21B.

Pudhom Khanitha K Teerawatananond Thapong T Chookpaiboon Supichar S

Marine drugs 20140306 3

Three new spirobisnaphthalenes (1-3) were isolated from the mangrove-derived fungus Rhytidhysteron sp., together with five known derivatives (4-8). The structures of the compounds were established on the basis of extensive spectroscopic data, and the relative configurations of their stereogenic carbons were determined by a single-crystal X-ray crystallographic analysis. Compounds 3-5 displayed cytotoxicity against both cancer cell lines, MCF-7 and CaSki, while 2 was active only on CaSKi cells. ...[more]

PMID: 24663115

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