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Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1.

ABSTRACT: Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-β-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh₂(OCOCF₃)₄-induced ECD experiments, and Marfey's method. Compound 1 showed cytotoxicity against the K562 cell line with IC₅₀ values of 13.10 ± 0.08 μM. Moreover, compounds 1 and 5 exhibited inhibitory activity against α-glycosidase with IC₅₀ values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively.

SUBMITTER: Cao X

PROVIDER: S-EPMC8717711 | biostudies-literature |

REPOSITORIES: biostudies-literature

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