Antigen-Specific Development of Mucosal Foxp3+ROR?t+ T Cells from Regulatory T Cell Precursors.

ABSTRACT: Foxp3+retinoic acid-related orphan receptor (ROR)?t+ T cells have recently been characterized as an immunoregulatory population highly enriched in the colon lamina propria. However, their developmental origin and relationship to ROR?t- regulatory T and Th17 cells remain unclear. In this study, we use a fixed TCR? system to show that the TCR repertoire of the Foxp3+ROR?t+ population is mostly distinct compared with other colonic T cell subsets. However, of these TCRs, a fraction is also found in the Th17 subset, suggesting that TCR repertoire overlap may contribute to the reported ability of Foxp3+ROR?t+ cells to regulate Th17 immunity. Naive transgenic T cells expressing a Foxp3+ROR?t+-restricted TCR first acquire a Foxp3+ROR?t- phenotype before coexpressing ROR?t, suggesting that Foxp3+ROR?t+ cell development can occur via an ROR?t- regulatory T cell intermediate.

SUBMITTER: Solomon BD 

PROVIDER: S-EPMC5101183 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature