Genome-wide association study for risk taking propensity indicates shared pathways with body mass index.
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ABSTRACT:
SUBMITTER: Clifton EAD
PROVIDER: S-EPMC6123697 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Genome-wide association study for risk taking propensity indicates shared pathways with body mass index.
Clifton Emma A D EAD Perry John R B JRB Imamura Fumiaki F Lotta Luca A LA Brage Soren S Forouhi Nita G NG Griffin Simon J SJ Wareham Nicholas J NJ Ong Ken K KK Day Felix R FR
Communications biology 20180503
Risk-taking propensity is a trait of significant public health relevance but few specific genetic factors are known. Here we perform a genome-wide association study of self-reported risk-taking propensity among 436,236 white European UK Biobank study participants. We identify genome-wide associations at 26 loci (<i>P</i> < 5 × 10<sup>-8</sup>), 24 of which are novel, implicating genes enriched in the GABA and GABA receptor pathways. Modelling the relationship between risk-taking propensity and b ...[more]
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