Ontology highlight
ABSTRACT:
SUBMITTER: Carregaro V
PROVIDER: S-EPMC5107840 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Carregaro Vanessa V Napimoga Marcelo H MH Peres Raphael S RS Benevides Luciana L Sacramento Laís Amorim LA Pinto Larissa G LG Grespan Renata R Cunha Thiago M TM da Silva João Santana JS Cunha Fernando Q FQ
Mediators of inflammation 20161031
The prostaglandin, 15-deoxy Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> (15d-PGJ<sub>2</sub>), is a lipid mediator that plays an important role in the control of chronic inflammatory disease. However, the role of prostanoid in rheumatoid arthritis (RA) is not well determined. We demonstrated the therapeutic effect of 15d-PGJ<sub>2</sub> in an experimental model of arthritis. Daily administration of 15d-PGJ<sub>2</sub> attenuated the severity of CIA, reducing the clinical score, pain, and edema ...[more]