Structural and genomic variation in preterm birth.
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ABSTRACT:
SUBMITTER: Uzun A
PROVIDER: S-EPMC5112111 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Structural and genomic variation in preterm birth.
Uzun Alper A Sahin Yavuz Y Schuster Jessica S JS Zheng Xiaojing X Ryckman Kelli K Feingold Eleanor E Padbury James J
Pediatric research 20160724 6
<h4>Background</h4>Runs of homozygosity (ROH) are consecutive homozygous genotypes, which may result from population inbreeding or consanguineous marriages. ROH enhance the expression of recessive traits.<h4>Methods</h4>We mapped ROH in a case control study of women delivering at term compared with women delivering at or before 34 wk gestation. Gene sets known to be important in risk of preterm birth were examined for their overlap with identified ROH segments.<h4>Results</h4>While we found no e ...[more]
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