Targeting Triple Negative Breast Cancer with a Small-sized Paramagnetic Nanoparticle.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC5180609 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Targeting Triple Negative Breast Cancer with a Small-sized Paramagnetic Nanoparticle.
Zhang Li L Varma Nadimpalli Rs NR Gang Zhang Z ZZ Ewing James R JR Arbab Ali S AS Ali Meser M MM
Journal of nanomedicine & nanotechnology 20161028 5
There is no available targeted therapy or imaging agent for triple negative breast cancer (TNBC). We developed a small-sized dendrimer-based nanoparticle containing a clinical relevant MRI contrast agent, GdDOTA and a NIR fluorescent dye, DL680. Systemic delivery of dual-modal nanoparticles led to accumulation of the agents in a flank mouse model of TNBC that were detected by both optical and MR imaging. <i>In-vivo</i> fluorescence images, as well as <i>ex-vivo</i> fluorescence images of individ ...[more]
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