Ontology highlight
ABSTRACT:
SUBMITTER: Aslund AK
PROVIDER: S-EPMC5196882 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Åslund Andreas K O AK Snipstad Sofie S Healey Andrew A Kvåle Svein S Torp Sverre H SH Sontum Per C PC Davies Catharina de Lange CL van Wamel Annemieke A
Theranostics 20170101 1
The blood-brain barrier (BBB) is a major obstacle in drug delivery for diseases of the brain, and today there is no standardized route to surpass it. One technique to locally and transiently disrupt the BBB, is focused ultrasound in combination with gas-filled microbubbles. However, the microbubbles used are typically developed for ultrasound imaging, not BBB disruption. Here we describe efficient opening of the BBB using the promising novel Acoustic Cluster Therapy (ACT), that recently has been ...[more]