Ontology highlight
ABSTRACT:
SUBMITTER: King HO
PROVIDER: S-EPMC5233453 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
King Harry O HO Brend Tim T Payne Helen L HL Wright Alexander A Ward Thomas A TA Patel Karan K Egnuni Teklu T Stead Lucy F LF Patel Anjana A Wurdak Heiko H Short Susan C SC
Stem cell reports 20170101 1
Patients with glioblastoma die from local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought to be due to efficient DNA double-strand break (DSB) repair in stem-like cells able to survive DNA damage and repopulate the tumor. We used clinical samples and patient-derived glioblastoma stem cells (GSCs) to confirm that the DSB repair protein RAD51 is highly expressed in GSCs, which are reliant on RAD51-dependent DSB repair after radiation. RAD51 expression and ...[more]