Ontology highlight
ABSTRACT:
SUBMITTER: King JK
PROVIDER: S-EPMC5237642 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Frontiers in immunology 20170116
B-cell development in the bone marrow is followed by specification into functional subsets in the spleen, including marginal zone (MZ) B-cells. MZ B-cells are classically characterized by T-independent antigenic responses and require the elaboration of distinct gene expression programs for development. Given their role in gene regulation, it is not surprising that microRNAs are important factors in B-cell development. Recent work demonstrated that deficiency of the NFκB feedback regulator, miR-1 ...[more]