Ontology highlight
ABSTRACT:
SUBMITTER: Adel M
PROVIDER: S-EPMC5271310 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Adel Mohamed M Yamaguchi Tetsutaro T Tomita Daisuke D Nakawaki Takatoshi T Kim Yong-Il YI Hikita Yu Y Haga Shugo S Takahashi Masahiro M Nadim Mohamed A MA Kawaguchi Akira A Isa Mutsumi M El-Kenany Walid H WH El-Kadi Abbadi A AA Park Soo-Byung SB Ishida Hajime H Maki Koutaro K Kimura Ryosuke R
PloS one 20170127 1
FGFR1 plays an important role in the development of the nervous system as well as the regulation of the skeletal development and bone homeostasis. Mutations in FGFR1 genes affect skull development, specifically suture and synchondrosis, resulting in craniosynostosis and facial abnormalities. We examined subjects with normal skull morphology for genetic polymorphisms that might be associated with normal craniofacial variations. Genomic DNA was obtained from 216 Japanese and 227 Korean subjects. F ...[more]