Ontology highlight
ABSTRACT:
SUBMITTER: Bonnin RA
PROVIDER: S-EPMC5278729 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Bonnin Rémy A RA Didi Jennifer J Ergani Ayla A Lima Sandra S Naas Thierry T
Antimicrobial agents and chemotherapy 20170124 2
Whole-genome sequencing of Serratia rubidaea CIP 103234<sup>T</sup> revealed a chromosomally located Ambler class A β-lactamase gene. The gene was cloned, and the β-lactamase, RUB-1, was characterized. RUB-1 displayed 74% and 73% amino acid sequence identity with the GIL-1 and TEM-1 penicillinases, respectively, and its substrate profile was similar to that of the latter β-lactamases. Analysis by 5' rapid amplification of cDNA ends revealed promoter sequences highly divergent from the Escherichi ...[more]