Gap junctions and cancer: communicating for 50 years.
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ABSTRACT:
SUBMITTER: Aasen T
PROVIDER: S-EPMC5279857 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Gap junctions and cancer: communicating for 50 years.
Aasen Trond T Mesnil Marc M Naus Christian C CC Lampe Paul D PD Laird Dale W DW
Nature reviews. Cancer 20161021 12
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis that loss of direct intercellular communication is commonly associated with cancer onset and progression. Subsequent studies linked this phenomenon to gap junctions composed of connexin proteins. Although many studies support the notion that connexins are tumour suppressors, recent evidence suggests that, in some tumour types, they may facilitate specific stages of tumour progression through both junc ...[more]
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