Ontology highlight
ABSTRACT:
SUBMITTER: Sendoel A
PROVIDER: S-EPMC5287289 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Sendoel Ataman A Dunn Joshua G JG Rodriguez Edwin H EH Naik Shruti S Gomez Nicholas C NC Hurwitz Brian B Levorse John J Dill Brian D BD Schramek Daniel D Molina Henrik H Weissman Jonathan S JS Fuchs Elaine E
Nature 20170111 7638
We are just beginning to understand how translational control affects tumour initiation and malignancy. Here we use an epidermis-specific, in vivo ribosome profiling strategy to investigate the translational landscape during the transition from normal homeostasis to malignancy. Using a mouse model of inducible SOX2, which is broadly expressed in oncogenic RAS-associated cancers, we show that despite widespread reductions in translation and protein synthesis, certain oncogenic mRNAs are spared. D ...[more]