Ontology highlight
ABSTRACT:
SUBMITTER: Ruan Y
PROVIDER: S-EPMC5320997 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170130 7
Glutamate transporters are essential for recovery of the neurotransmitter glutamate from the synaptic cleft. Crystal structures in the outward- and inward-facing conformations of a glutamate transporter homolog from archaebacterium <i>Pyrococcus horikoshii</i>, sodium/aspartate symporter Glt<sub>Ph</sub>, suggested the molecular basis of the transporter cycle. However, dynamic studies of the transport mechanism have been sparse and indirect. Here we present high-speed atomic force microscopy (HS ...[more]