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Fluorinative ring-opening of cyclopropanes by hypervalent iodine reagents. An efficient method for 1,3-oxyfluorination and 1,3-difluorination.

ABSTRACT: A new method is presented for 1,3-difluorination and 1,3-oxyfluorination reactions. The process is based on iodonium mediated opening of 1,1-disubstituted cyclopropanes. The reaction proceeds with high chemo- and regioselectivity under mild reaction conditions typically at room temperature in a couple of hours. The reaction probably occurs via electrophilic ring-opening of cyclopropanes.

SUBMITTER: Ilchenko NO

PROVIDER: S-EPMC5356504 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Fluorinative ring-opening of cyclopropanes by hypervalent iodine reagents. An efficient method for 1,3-oxyfluorination and 1,3-difluorination.

Ilchenko Nadia O NO Hedberg Martin M Szabó Kálmán J KJ

Chemical science 20160916 2

A new method is presented for 1,3-difluorination and 1,3-oxyfluorination reactions. The process is based on iodonium mediated opening of 1,1-disubstituted cyclopropanes. The reaction proceeds with high chemo- and regioselectivity under mild reaction conditions typically at room temperature in a couple of hours. The reaction probably occurs <i>via</i> electrophilic ring-opening of cyclopropanes. ...[more]

PMID: 28451244

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