Ontology highlight
ABSTRACT:
SUBMITTER: Jang J
PROVIDER: S-EPMC5358930 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Jang Jiryeon J Rath Oliver O Schueler Julia J Sung Hyun Hwan HH Jeon Hwang Gyun HG Jeong Byong Chang BC Seo Seong Il SI Jeon Seong Soo SS Lee Hyun Moo HM Choi Han-Yong HY Kwon Ghee-Young GY Park Woong Yang WY Lee Jeeyun J Park Se Hoon SH
Translational oncology 20170316 3
<h4>Purpose</h4>Although targeting angiogenesis with tyrosine kinase inhibitors (TKIs) has become standard of care in the treatment of clear cell renal cell carcinoma (RCC), resistance mechanism are not fully understood, and there is a need to develop new therapeutic options overcoming them.<h4>Methods and materials</h4>To develop a preclinical model that predicts clinical activity of novel agents in 19 RCC patients, we established patient-derived cell (PDC) and xenograft (PDX) models derived fr ...[more]