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Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes.

ABSTRACT: The regio- and diastereoselective zirconocene-catalyzed carbomagnesiation of cyclobutenes is herein reported to afford configurationally stable cyclobutylmagnesium species that could subsequently react with a large variety of electrophiles to give polysubstituted cyclobutane species as a single diastereoisomer.

SUBMITTER: Roy SR

PROVIDER: S-EPMC5365058 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes.

Roy Sudipta Raha SR Eijsberg Hendrik H Bruffaerts Jeffrey J Marek Ilan I

Chemical science 20160830 1

The regio- and diastereoselective zirconocene-catalyzed carbomagnesiation of cyclobutenes is herein reported to afford configurationally stable cyclobutylmagnesium species that could subsequently react with a large variety of electrophiles to give polysubstituted cyclobutane species as a single diastereoisomer. ...[more]

PMID: 28451177

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