Ontology highlight
ABSTRACT:
SUBMITTER: Silvestri AP
PROVIDER: S-EPMC5584686 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20170608 24
Amphiphilic fluorocarbons have unique properties that facilitate their self assembly and adhesion to both inorganic and biological substrates. Incorporation of these moieties into valuable constructs typically require complex synthetic routes that have limited their use. Here, the base-catalyzed diastereoselective synthesis of 6-methyl-2,4,6-tris(trifluoromethyl)tetrahydro-2H-pyran-2,4-diol is reported. Trimerization of trifluoroacetone in the presence of 5 mol% KHMDS delivers one of four diaste ...[more]