Ontology highlight
ABSTRACT:
SUBMITTER: Chen CC
PROVIDER: S-EPMC5382965 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Chen Claire C CC Liu Linan L Ma Fengxia F Wong Chi W CW Guo Xuning E XE Chacko Jenu V JV Farhoodi Henry P HP Zhang Shirley X SX Zimak Jan J Ségaliny Aude A Riazifar Milad M Pham Victor V Digman Michelle A MA Pone Egest J EJ Zhao Weian W
Cellular and molecular bioengineering 20160707 4
The delivery of therapeutics to the central nervous system (CNS) remains a major challenge in part due to the presence of the blood-brain barrier (BBB). Recently, cell-derived vesicles, particularly exosomes, have emerged as an attractive vehicle for targeting drugs to the brain, but whether or how they cross the BBB remains unclear. Here, we investigated the interactions between exosomes and brain microvascular endothelial cells (BMECs) <i>in vitro</i> under conditions that mimic the healthy an ...[more]