Ontology highlight
ABSTRACT:
SUBMITTER: Appleby TC
PROVIDER: S-EPMC538717 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Appleby Todd C TC Luecke Hartmut H Shim Jae Hoon JH Wu Jim Z JZ Cheney I Wayne IW Zhong Weidong W Vogeley Lutz L Hong Zhi Z Yao Nanhua N
Journal of virology 20050101 1
Picornaviruses utilize virally encoded RNA polymerase and a uridylylated protein primer to ensure replication of the entire viral genome. The molecular details of this mechanism are not well understood due to the lack of structural information. We report the crystal structure of human rhinovirus 16 3D RNA-dependent RNA polymerase (HRV16 3Dpol) at a 2.4-A resolution, representing the first complete polymerase structure from the Picornaviridae family. HRV16 3Dpol shares the canonical features of o ...[more]