Ontology highlight
ABSTRACT:
SUBMITTER: Kalisiak K
PROVIDER: S-EPMC5389692 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Kalisiak Katarzyna K Kuliński Tomasz M TM Tomecki Rafał R Cysewski Dominik D Pietras Zbigniew Z Chlebowski Aleksander A Kowalska Katarzyna K Dziembowski Andrzej A
Nucleic acids research 20170201 4
The exosome complex is a major eukaryotic exoribonuclease that requires the SKI complex for its activity in the cytoplasm. In yeast, the Ski7 protein links both complexes, whereas a functional equivalent of the Ski7 has remained unknown in the human genome. Proteomic analysis revealed that a previously uncharacterized short splicing isoform of HBS1L (HBS1LV3) is the long-sought factor linking the exosome and SKI complexes in humans. In contrast, the canonical HBS1L variant, HBS1LV1, which acts a ...[more]