Ontology highlight
ABSTRACT:
SUBMITTER: Zhang E
PROVIDER: S-EPMC6627227 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zhang Elodie E Khanna Varun V Dacheux Estelle E Namane Abdelkader A Doyen Antonia A Gomard Maïté M Turcotte Bernard B Jacquier Alain A Fromont-Racine Micheline M
The EMBO journal 20190607 14
The Ski2-Ski3-Ski8 (SKI) complex assists the RNA exosome during the 3' to 5' degradation of cytoplasmic transcripts. Previous reports showed that the SKI complex is involved in the 3' to 5' degradation of mRNAs, including 3' untranslated regions (UTRs) and devoid of ribosomes. Paradoxically, we recently showed that the SKI complex directly interacts with ribosomes during the co-translational mRNA decay and that this interaction is necessary for its RNA degradation promoting activity. Here, we ch ...[more]