Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
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ABSTRACT:
SUBMITTER: Justice AE
PROVIDER: S-EPMC5414044 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Justice Anne E AE Winkler Thomas W TW Feitosa Mary F MF Graff Misa M Fisher Virginia A VA Young Kristin K Barata Llilda L Deng Xuan X Czajkowski Jacek J Hadley David D Ngwa Julius S JS Ahluwalia Tarunveer S TS Chu Audrey Y AY Heard-Costa Nancy L NL Lim Elise E Perez Jeremiah J Eicher John D JD Kutalik Zoltán Z Xue Luting L Mahajan Anubha A Renström Frida F Wu Joseph J Qi Qibin Q Ahmad Shafqat S Alfred Tamuno T Amin Najaf N Bielak Lawrence F LF Bonnefond Amelie A Bragg Jennifer J Cadby Gemma G Chittani Martina M Coggeshall Scott S Corre Tanguy T Direk Nese N Eriksson Joel J Fischer Krista K Gorski Mathias M Neergaard Harder Marie M Horikoshi Momoko M Huang Tao T Huffman Jennifer E JE Jackson Anne U AU Justesen Johanne Marie JM Kanoni Stavroula S Kinnunen Leena L Kleber Marcus E ME Komulainen Pirjo P Kumari Meena M Lim Unhee U Luan Jian'an J Lyytikäinen Leo-Pekka LP Mangino Massimo M Manichaikul Ani A Marten Jonathan J Middelberg Rita P S RPS Müller-Nurasyid Martina M Navarro Pau P Pérusse Louis L Pervjakova Natalia N Sarti Cinzia C Smith Albert Vernon AV Smith Jennifer A JA Stančáková Alena A Strawbridge Rona J RJ Stringham Heather M HM Sung Yun Ju YJ Tanaka Toshiko T Teumer Alexander A Trompet Stella S van der Laan Sander W SW van der Most Peter J PJ Van Vliet-Ostaptchouk Jana V JV Vedantam Sailaja L SL Verweij Niek N Vink Jacqueline M JM Vitart Veronique V Wu Ying Y Yengo Loic L Zhang Weihua W Hua Zhao Jing J Zimmermann Martina E ME Zubair Niha N Abecasis Gonçalo R GR Adair Linda S LS Afaq Saima S Afzal Uzma U Bakker Stephan J L SJL Bartz Traci M TM Beilby John J Bergman Richard N RN Bergmann Sven S Biffar Reiner R Blangero John J Boerwinkle Eric E Bonnycastle Lori L LL Bottinger Erwin E Braga Daniele D Buckley Brendan M BM Buyske Steve S Campbell Harry H Chambers John C JC Collins Francis S FS Curran Joanne E JE de Borst Gert J GJ de Craen Anton J M AJM de Geus Eco J C EJC Dedoussis George G Delgado Graciela E GE den Ruijter Hester M HM Eiriksdottir Gudny G Eriksson Anna L AL Esko Tõnu T Faul Jessica D JD Ford Ian I Forrester Terrence T Gertow Karl K Gigante Bruna B Glorioso Nicola N Gong Jian J Grallert Harald H Grammer Tanja B TB Grarup Niels N Haitjema Saskia S Hallmans Göran G Hamsten Anders A Hansen Torben T Harris Tamara B TB Hartman Catharina A CA Hassinen Maija M Hastie Nicholas D ND Heath Andrew C AC Hernandez Dena D Hindorff Lucia L Hocking Lynne J LJ Hollensted Mette M Holmen Oddgeir L OL Homuth Georg G Jan Hottenga Jouke J Huang Jie J Hung Joseph J Hutri-Kähönen Nina N Ingelsson Erik E James Alan L AL Jansson John-Olov JO Jarvelin Marjo-Riitta MR Jhun Min A MA Jørgensen Marit E ME Juonala Markus M Kähönen Mika M Karlsson Magnus M Koistinen Heikki A HA Kolcic Ivana I Kolovou Genovefa G Kooperberg Charles C Krämer Bernhard K BK Kuusisto Johanna J Kvaløy Kirsti K Lakka Timo A TA Langenberg Claudia C Launer Lenore J LJ Leander Karin K Lee Nanette R NR Lind Lars L Lindgren Cecilia M CM Linneberg Allan A Lobbens Stephane S Loh Marie M Lorentzon Mattias M Luben Robert R Lubke Gitta G Ludolph-Donislawski Anja A Lupoli Sara S Madden Pamela A F PAF Männikkö Reija R Marques-Vidal Pedro P Martin Nicholas G NG McKenzie Colin A CA McKnight Barbara B Mellström Dan D Menni Cristina C Montgomery Grant W GW Musk Aw Bill AB Narisu Narisu N Nauck Matthias M Nolte Ilja M IM Oldehinkel Albertine J AJ Olden Matthias M Ong Ken K KK Padmanabhan Sandosh S Peyser Patricia A PA Pisinger Charlotta C Porteous David J DJ Raitakari Olli T OT Rankinen Tuomo T Rao D C DC Rasmussen-Torvik Laura J LJ Rawal Rajesh R Rice Treva T Ridker Paul M PM Rose Lynda M LM Bien Stephanie A SA Rudan Igor I Sanna Serena S Sarzynski Mark A MA Sattar Naveed N Savonen Kai K Schlessinger David D Scholtens Salome S Schurmann Claudia C Scott Robert A RA Sennblad Bengt B Siemelink Marten A MA Silbernagel Günther G Slagboom P Eline PE Snieder Harold H Staessen Jan A JA Stott David J DJ Swertz Morris A MA Swift Amy J AJ Taylor Kent D KD Tayo Bamidele O BO Thorand Barbara B Thuillier Dorothee D Tuomilehto Jaakko J Uitterlinden Andre G AG Vandenput Liesbeth L Vohl Marie-Claude MC Völzke Henry H Vonk Judith M JM Waeber Gérard G Waldenberger Melanie M Westendorp R G J RGJ Wild Sarah S Willemsen Gonneke G Wolffenbuttel Bruce H R BHR Wong Andrew A Wright Alan F AF Zhao Wei W Zillikens M Carola MC Baldassarre Damiano D Balkau Beverley B Bandinelli Stefania S Böger Carsten A CA Boomsma Dorret I DI Bouchard Claude C Bruinenberg Marcel M Chasman Daniel I DI Chen Yii-DerIda YD Chines Peter S PS Cooper Richard S RS Cucca Francesco F Cusi Daniele D Faire Ulf de U Ferrucci Luigi L Franks Paul W PW Froguel Philippe P Gordon-Larsen Penny P Grabe Hans-Jörgen HJ Gudnason Vilmundur V Haiman Christopher A CA Hayward Caroline C Hveem Kristian K Johnson Andrew D AD Wouter Jukema J J Kardia Sharon L R SLR Kivimaki Mika M Kooner Jaspal S JS Kuh Diana D Laakso Markku M Lehtimäki Terho T Marchand Loic Le LL März Winfried W McCarthy Mark I MI Metspalu Andres A Morris Andrew P AP Ohlsson Claes C Palmer Lyle J LJ Pasterkamp Gerard G Pedersen Oluf O Peters Annette A Peters Ulrike U Polasek Ozren O Psaty Bruce M BM Qi Lu L Rauramaa Rainer R Smith Blair H BH Sørensen Thorkild I A TIA Strauch Konstantin K Tiemeier Henning H Tremoli Elena E van der Harst Pim P Vestergaard Henrik H Vollenweider Peter P Wareham Nicholas J NJ Weir David R DR Whitfield John B JB Wilson James F JF Tyrrell Jessica J Frayling Timothy M TM Barroso Inês I Boehnke Michael M Deloukas Panagiotis P Fox Caroline S CS Hirschhorn Joel N JN Hunter David J DJ Spector Tim D TD Strachan David P DP van Duijn Cornelia M CM Heid Iris M IM Mohlke Karen L KL Marchini Jonathan J Loos Ruth J F RJF Kilpeläinen Tuomas O TO Liu Ching-Ti CT Borecki Ingrid B IB North Kari E KE Cupples L Adrienne LA
Nature communications 20170426
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with conv ...[more]