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Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.

ABSTRACT: Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and maintenance of dendrites and functional spines are independent of synaptic glutamate release.

SUBMITTER: Sigler A

PROVIDER: S-EPMC5418202 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.

Sigler Albrecht A Oh Won Chan WC Imig Cordelia C Altas Bekir B Kawabe Hiroshi H Cooper Benjamin H BH Kwon Hyung-Bae HB Rhee Jeong-Seop JS Brose Nils N

Neuron 20170401 2

Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and main ...[more]

PMID: 28426965

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