Ontology highlight
ABSTRACT:
SUBMITTER: Cignetto S
PROVIDER: S-EPMC5423175 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cignetto Simona S Modica Chiara C Chiriaco Cristina C Fontani Lara L Milla Paola P Michieli Paolo P Comoglio Paolo M PM Vigna Elisa E
Molecular oncology 20160328 6
The kinase receptor encoded by the Met oncogene is a sensible target for cancer therapy. The chimeric monovalent Fab fragment of the DN30 monoclonal antibody (MvDN30) has an odd mechanism of action, based on cell surface removal of Met via activation of specific plasma membrane proteases. However, the short half-life of the Fab, due to its low molecular weight, is a severe limitation for the deployment in therapy. This issue was addressed by increasing the Fab molecular weight above the glomerul ...[more]