Hypothesis: The unfolding power of protein dielectricity.
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ABSTRACT:
SUBMITTER: Uversky VN
PROVIDER: S-EPMC5424796 | biostudies-literature | 2013 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
Hypothesis: The unfolding power of protein dielectricity.
Intrinsically disordered proteins 20130101 1
A hypothesis is proposed on a potential role of protein dielectricity as an unfolding factor in protein-protein interactions. It is suggested that large protein complexes and aggregation seeds can unfold target proteins by virtue of their effect on the dielectric properties of water at the protein-solvent interface. Here, similar to the effect of membrane surfaces, protein surface can cause decrease in the local dielectric constant of solvent and thereby induce structural changes in a target pro ...[more]
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