Ontology highlight
ABSTRACT:
SUBMITTER: Bezzerides VJ
PROVIDER: S-EPMC5428512 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Bezzerides Vassilios J VJ Zhang Aifeng A Xiao Ling L Simonson Bridget B Khedkar Santosh A SA Baba Shiro S Ottaviano Filomena F Lynch Stacey S Hessler Katherine K Rigby Alan C AC Milan David D Das Saumya S Rosenzweig Anthony A
Scientific reports 20170323 1
Alterations in sodium flux (I<sub>Na</sub>) play an important role in the pathogenesis of cardiac arrhythmias and may also contribute to the development of cardiomyopathies. We have recently demonstrated a critical role for the regulation of the voltage-gated sodium channel Na<sub>V</sub>1.5 in the heart by the serum and glucocorticoid regulated kinase-1 (SGK1). Activation of SGK1 in the heart causes a marked increase in both the peak and late sodium currents leading to prolongation of the actio ...[more]