Ontology highlight
ABSTRACT:
SUBMITTER: Pollack RA
PROVIDER: S-EPMC5433942 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Pollack Ross A RA Jones R Brad RB Pertea Mihaela M Bruner Katherine M KM Martin Alyssa R AR Thomas Allison S AS Capoferri Adam A AA Beg Subul A SA Huang Szu-Han SH Karandish Sara S Hao Haiping H Halper-Stromberg Eitan E Yong Patrick C PC Kovacs Colin C Benko Erika E Siliciano Robert F RF Ho Ya-Chi YC
Cell host & microbe 20170401 4
Despite antiretroviral therapy, HIV-1 persists in memory CD4<sup>+</sup> T cells, creating a barrier to cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant. Using cells from HIV-1-infected individuals and reconstructed patient-derived defective proviruses, we show that defective proviruses can be transcribed into RNAs that are spliced and translated. Proviruses with defective major splice donors (MSDs) can activate novel splice sites to produce HIV-1 transcr ...[more]