Ontology highlight
ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC5451214 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Xu Chiwei C Luo Junjie J He Li L Montell Craig C Perrimon Norbert N
eLife 20170531
Precise regulation of stem cell activity is crucial for tissue homeostasis and necessary to prevent overproliferation. In the <i>Drosophila</i> adult gut, high levels of reactive oxygen species (ROS) has been detected with different types of tissue damage, and oxidative stress has been shown to be both necessary and sufficient to trigger intestinal stem cell (ISC) proliferation. However, the connection between oxidative stress and mitogenic signals remains obscure. In a screen for genes required ...[more]