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Common genetic variation in the germline influences where and how tumors develop.

ABSTRACT: Germline variation contributes to individual risk for developing specific types of cancer. Analyzing thousands of tumors, we found evidence that the germline also influences vulnerable tissue sites and the mutations that arise in tumor genomes. These associations provide new clues to unravel the biologic mechanisms underlying cancer predisposition.

SUBMITTER: Carter H

PROVIDER: S-EPMC5462515 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Common genetic variation in the germline influences where and how tumors develop.

Carter Hannah H Ideker Trey T

Molecular & cellular oncology 20170310 3

Germline variation contributes to individual risk for developing specific types of cancer. Analyzing thousands of tumors, we found evidence that the germline also influences vulnerable tissue sites and the mutations that arise in tumor genomes. These associations provide new clues to unravel the biologic mechanisms underlying cancer predisposition. ...[more]

PMID: 28616579

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