Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC5472614 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wang Qiang Q Zhang Yixuan Y Wang Mian M Tan Yi Y Hu Xinxin X He Hongwei H Xiao Chunling C You Xuefu X Wang Yiguang Y Gan Maoluo M
Scientific reports 20170615 1
Neo-actinomycins A and B (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5H-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete Streptomyces sp. IMB094. Their structures were elucidated by spectroscopic analyses. The presence of this ring system was proposed to originate from a condensation between actinomycin D (3) with α-ketoglutarate and pyruvate, respectively. Compound 1 showed potent cytotoxic activities against human canc ...[more]