Unknown

Dataset Information

0

Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094.


ABSTRACT: Neo-actinomycins A and B (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5H-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete Streptomyces sp. IMB094. Their structures were elucidated by spectroscopic analyses. The presence of this ring system was proposed to originate from a condensation between actinomycin D (3) with ?-ketoglutarate and pyruvate, respectively. Compound 1 showed potent cytotoxic activities against human cancer HCT116 and A549 cell lines in the nanomolar range (IC50: 38.7 and 65.8?nM, respectively) and moderate antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) strains.

SUBMITTER: Wang Q 

PROVIDER: S-EPMC5472614 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094.

Wang Qiang Q   Zhang Yixuan Y   Wang Mian M   Tan Yi Y   Hu Xinxin X   He Hongwei H   Xiao Chunling C   You Xuefu X   Wang Yiguang Y   Gan Maoluo M  

Scientific reports 20170615 1


Neo-actinomycins A and B (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5H-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete Streptomyces sp. IMB094. Their structures were elucidated by spectroscopic analyses. The presence of this ring system was proposed to originate from a condensation between actinomycin D (3) with α-ketoglutarate and pyruvate, respectively. Compound 1 showed potent cytotoxic activities against human canc  ...[more]

Similar Datasets

| S-EPMC5082329 | biostudies-literature
| S-EPMC5487404 | biostudies-literature
| S-EPMC5418784 | biostudies-literature
| S-EPMC3344565 | biostudies-literature
| S-EPMC3702164 | biostudies-literature
| S-EPMC10459128 | biostudies-literature
| S-EPMC9587877 | biostudies-literature
| S-EPMC6381723 | biostudies-literature
| S-EPMC7544235 | biostudies-literature
| S-EPMC6201156 | biostudies-literature