Ontology highlight
ABSTRACT:
SUBMITTER: Neves J
PROVIDER: S-EPMC5478206 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
EBioMedicine 20170429
Emerging evidence suggests that pulmonary iron accumulation is implicated in a spectrum of chronic lung diseases. However, the mechanism(s) involved in pulmonary iron deposition and its role in the in vivo pathogenesis of lung diseases remains unknown. Here we show that a point mutation in the murine ferroportin gene, which causes hereditary hemochromatosis type 4 (Slc40a1<sup>C326S</sup>), increases iron levels in alveolar macrophages, epithelial cells lining the conducting airways and lung par ...[more]