Ontology highlight
ABSTRACT:
SUBMITTER: Gomes AS
PROVIDER: S-EPMC5979565 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Gomes Ana Sara AS Trovão Filipa F Andrade Pinheiro Benedita B Freire Filipe F Gomes Sara S Oliveira Carla C Domingues Lucília L Romão Maria João MJ Saraiva Lucília L Carvalho Ana Luísa AL
International journal of molecular sciences 20180413 4
The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as a molecular hub regulating different cell responses, namely cell death. Compelling data have demonstrated that the impairment of p53 activity correlates with tumor development and maintenance. For these reasons, the reactivation of p53 function is regarded as a promising strategy to halt cancer. In the present work, the recombinant mutant p53R280K DNA binding domain (DBD) was produced for the firs ...[more]