Ontology highlight
ABSTRACT:
SUBMITTER: Nelson AC
PROVIDER: S-EPMC5494305 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nelson Andrew C AC Cutty Stephen J SJ Gasiunas Saule N SN Deplae Isabella I Stemple Derek L DL Wardle Fiona C FC
Cell reports 20170601 13
T-box transcription factors T/Brachyury homolog A (Ta) and Tbx16 are essential for correct mesoderm development in zebrafish. The downstream transcriptional networks guiding their functional activities are poorly understood. Additionally, important contributions elsewhere are likely masked due to redundancy. Here, we exploit functional genomic strategies to identify Ta and Tbx16 targets in early embryogenesis. Surprisingly, we discovered they not only activate mesodermal gene expression but also ...[more]