Ontology highlight
ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC5502736 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Lu Jiaxiong J Guan Shan S Zhao Yanling Y Yu Yang Y Woodfield Sarah E SE Zhang Huiyuan H Yang Kristine L KL Bieerkehazhi Shayahati S Qi Lin L Li Xiaonan X Gu Jerry J Xu Xin X Jin Jingling J Muscal Jodi A JA Yang Tianshu T Xu Guo-Tong GT Yang Jianhua J
Cancer letters 20170426
Activating germline mutations of anaplastic lymphoma kinase (ALK) occur in most cases of hereditary neuroblastoma (NB) and the constitutively active kinase activity of ALK promotes cell proliferation and survival in NB. Therefore, ALK kinase is a potential therapeutic target for NB. In this study, we show that the novel ALK inhibitor alectinib effectively suppressed cell proliferation and induces apoptosis in NB cell lines with either wild-type ALK or mutated ALK (F1174L and D1091N) by blocking ...[more]