Ontology highlight
ABSTRACT:
SUBMITTER: Rozenberg P
PROVIDER: S-EPMC5517555 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Rozenberg Perri P Reichman Hadar H Zab-Bar Israel I Itan Michal M Pasmanik-Chor Metsada M Bouffi Carine C Qimron Udi U Bachelet Ido I Fulkerson Patricia C PC Rothenberg Marc E ME Munitz Ariel A
Scientific reports 20170719 1
Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 <sup>Tg</sup> /Cd300f <sup>-/-</sup> mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Co ...[more]