Ontology highlight
ABSTRACT:
SUBMITTER: Xu N
PROVIDER: S-EPMC5518618 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Xu Ningning N Ma Chao C Ou Jianfa J Sun Wanqi Wendy WW Zhou Lufang L Hu Hui H Liu Xiaoguang Margaret XM
Biochemical engineering journal 20170515
Chinese hamster ovary (CHO) cells have been widely used to express heterologous genes and produce therapeutic proteins in biopharmaceutical industry. Different CHO host cells have distinct cell growth rates and protein expression characteristics. In this study, the expression of about 1,307 host proteins in three sublines, i.e. CHO K1, CHO S and CHO/dihydrofolate reductase (<i>dhfr)<sup>-</sup></i> , were investigated and compared using proteomic analysis. The proteins involved in cell growth, g ...[more]