Ontology highlight
ABSTRACT:
SUBMITTER: Chen PH
PROVIDER: S-EPMC5538768 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Chen Po-Han PH Smith Timothy J TJ Wu Jianli J Siesser Priscila F PF Bisnett Brittany J BJ Khan Farhan F Hogue Maxwell M Soderblom Erik E Tang Flora F Marks Jeffrey R JR Major Michael B MB Swarts Benjamin M BM Boyce Michael M Chi Jen-Tsan JT
The EMBO journal 20170629 15
O-GlcNAcylation is an essential, nutrient-sensitive post-translational modification, but its biochemical and phenotypic effects remain incompletely understood. To address this question, we investigated the global transcriptional response to perturbations in O-GlcNAcylation. Unexpectedly, many transcriptional effects of O-GlcNAc transferase (OGT) inhibition were due to the activation of NRF2, the master regulator of redox stress tolerance. Moreover, we found that a signature of low OGT activity s ...[more]