Ontology highlight
ABSTRACT:
SUBMITTER: Simon E
PROVIDER: S-EPMC5542222 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Simon Einav E Bick Tova T Sarji Shada S Shentzer Talia T Prinz Elad E Yehiam Liza L Sabo Edmond E Ben-Izhak Ofer O Hershkovitz Dov D
Oncotarget 20170701 28
Genetic sub-clonality has been described in multiple malignancies, however the presence of sub-clonality for major drivers in lung adenocarcinoma and its clinical significance is a subject under debate. Using molecular and morphometric approach, 347 lung adenocarcinoma samples were analyzed for KRAS and EGFR sub-clonality, which was further correlated with clinical and pathological variables.KRAS and EGFR mutations were identified in 100 (29%) and 82 (23%) cases, respectively. One hundred and fo ...[more]