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Pd-Catalyzed Decarbonylative Cross-Couplings of Aroyl Chlorides.

ABSTRACT: This report describes a method for Pd-catalyzed decarbonylative cross-coupling that enables the conversion of carboxylic acid derivatives to biaryls, aryl amines, aryl ethers, aryl sulfides, aryl boronate esters, and trifluoromethylated arenes. The success of this transformation leverages the Pd0/Brettphos-catalyzed decarbonylative chlorination of aroyl chlorides, which can then participate in diverse cross-coupling reactions in situ using the same Pd catalyst.

SUBMITTER: Malapit CA 

PROVIDER: S-EPMC5565168 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Pd-Catalyzed Decarbonylative Cross-Couplings of Aroyl Chlorides.

Malapit Christian A CA   Ichiishi Naoko N   Sanford Melanie S MS  

Organic letters 20170719 15

This report describes a method for Pd-catalyzed decarbonylative cross-coupling that enables the conversion of carboxylic acid derivatives to biaryls, aryl amines, aryl ethers, aryl sulfides, aryl boronate esters, and trifluoromethylated arenes. The success of this transformation leverages the Pd<sup>0</sup>/Brettphos-catalyzed decarbonylative chlorination of aroyl chlorides, which can then participate in diverse cross-coupling reactions in situ using the same Pd catalyst. ...[more]

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