Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke.

ABSTRACT:

Background

While neurogranin has no value as plasma biomarker for Alzheimer's disease, it may be a potential blood biomarker for traumatic brain injury. This evokes the question whether there are changes in neurogranin levels in blood in other conditions of brain injury, such as acute ischemic stroke (AIS).

Methods

We therefore explored neurogranin in paired cerebrospinal fluid (CSF)/plasma samples of AIS patients (n = 50) from a well-described prospective study. In parallel, we investigated another neuronal protein, i.e. tau, which has already been suggested as potential AIS biomarker in CSF and blood. ELISA as well as Single Molecule Array (Simoa) technology were used for the biochemical analyses. Statistical analyses included Shapiro-Wilk testing, Mann-Whitney analyses an

SUBMITTER: De Vos A 

PROVIDER: S-EPMC5577791 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature