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Long intergenic non-coding RNA GALMD3 in chicken Marek's disease.

ABSTRACT: Long intergenic non-coding RNAs (lincRNAs) are transcribed from non-coding DNA sequences. Studies have revealed that aberrant expressions of lincRNAs are associated with various types of cancers and neurological disorders. Marek's disease (MD) is a highly contagious T-cell lymphoid neoplasia of chicken induced by Marek's disease virus (MDV). In this study, we first identified and validated linc-GALMD3 highly expressed in MDV-infected CD4+ T cells by RNA-Seq and qRT-PCR. By RNA-Seq analysis in MDCC-MSB1 cells after loss of function of linc-GALMD3 by shRNA, we found that linc-GALMD3 could positively cis-regulate its downstream gga-miR-223 gene expression. In contrast, it could trans-regulate the 748 differentially expressed genes (FDR?

SUBMITTER: Han B

PROVIDER: S-EPMC5579197 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Long intergenic non-coding RNA GALMD3 in chicken Marek's disease.

Han Bo B He Yanghua Y Zhang Li L Ding Yi Y Lian Ling L Zhao Chunfang C Song Jiuzhou J Yang Ning N

Scientific reports 20170831 1

Long intergenic non-coding RNAs (lincRNAs) are transcribed from non-coding DNA sequences. Studies have revealed that aberrant expressions of lincRNAs are associated with various types of cancers and neurological disorders. Marek's disease (MD) is a highly contagious T-cell lymphoid neoplasia of chicken induced by Marek's disease virus (MDV). In this study, we first identified and validated linc-GALMD3 highly expressed in MDV-infected CD4+ T cells by RNA-Seq and qRT-PCR. By RNA-Seq analysis in MD ...[more]

PMID: 28860661

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